Combining swallowable gastric balloon and anti-obesity drug may increase weight reduction success


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A brand new therapy for chubby and weight problems combining the world’s first and solely procedure-free swallowable gastric balloon—that’s positioned with out surgical procedure, endoscopy or anesthesia and passes out of the physique naturally after roughly 16 weeks—and the generally prescribed anti-obesity drug liraglutide, based on a brand new examine, is a secure and efficient approach to increase weight reduction.

The worldwide multi-center examine being introduced at this yr’s European Congress on Weight problems (ECO) in Dublin, Eire (Could 17-20), by Dr. Roberta Ienca on the Nuova Villa Claudia Clinic, Rome, Italy and colleagues, builds on earlier research that present that the Allurion Balloon (referred to as Elipse), which is folded right into a swallowable vegan capsule, is a straightforward, secure, and efficient technique for weight reduction.

Glucagon like peptide-1 receptor agonists (GLP-1 RAs) like liraglutide (Saxenda) have additionally been proven to be efficient in treating weight problems and kind 2 diabetes by enhancing emotions of fullness (satiety) and suppressing urge for food.

On this examine, researchers evaluated the efficacy and security of the Allurion Balloon together with the generally prescribed weight-loss drug liraglutide. A complete of 181 sufferers (145 ladies and 36 males) had been enrolled—their common age was 44 years previous, common weight earlier than therapy was 94.8kg, and common preliminary physique mass index (BMI) was 33.7kg/ m2.

The sufferers had been handled at three worldwide multidisciplinary weight problems facilities in Italy, Spain and Egypt.

The balloon is swallowed and stuffed with liquid after it reaches the abdomen. Placement is carried out in a 20-minute outpatient go to. The balloon normally stays within the affected person for 15-17 weeks, with a median of 16 weeks. It’s then excreted naturally.

Between 4 and 16 weeks after balloon placement, liraglutide was added as soon as each day to boost weight reduction and maximize the outcomes to extend affected person satisfaction. All 181 sufferers obtained liraglutide. Sufferers’ causes for including liraglutide had been: unsatisfactory weight reduction (53%), discount of balloon induced satiety (29%), to additional increase profitable weight reduction (16%) and diabetes management in these with passable weight reduction (2%).

After 16 weeks of balloon therapy, members misplaced a median 13kg and 14% of their preliminary physique weight (nicely above the 5-10% thought of clinically significant weight reduction). As well as, on common they shed 74% of extra weight (calculated utilizing a reference regular BMI of 25 kg/m2) and lowered their BMI by 4.5kg/m2. As sufferers started their liraglutide therapy earlier than the balloon was excreted, these first outcomes embrace the early results of liraglutide generally.

As soon as the balloon handed out of the physique, sufferers had been transitioned to a Mediterranean food regimen for weight upkeep and adopted for at the very least 6 months.

On the finish of the therapy with liraglutide (the common length was 4 months for liraglutide therapy), members misplaced on common 18kg and 19% of their preliminary physique weight. As well as, on common they shed 99% of their extra weight and lowered their BMI by 5.9kg/m2.

No critical adversarial occasions had been recorded. Different balloon associated adversarial occasions together with nausea, vomiting and belly cramps had been managed with treatment. As well as, 4 members had the balloon eliminated as a consequence of intolerance, gastric dilation, or early balloon deflation.

Liraglutide associated adversarial occasions included nausea (16.5%), diarrhea (3.3%), constipation (2.2%) and headache (1.7%). Total, 4 members discontinued drug remedy due to tachycardia/chest ache or gastrointestinal signs.

The authors clarify that though it’s more practical than medicine, food regimen, and train, intragastric balloon uptake has been restricted as a result of want for endoscopy for placement.

“These two therapy approaches seem to have complementary mechanisms of motion in a geographically and demographically numerous inhabitants,” says Dr. Ienca. “The Allurion Program delivers glorious weight reduction in people with chubby and weight problems with out going underneath the knife, and liraglutide has the potential to additional safely improve weight reduction in case of suboptimal adherence with this system and for sufferers which are aiming to additional increase the outcomes of therapy.”

She provides, “The benefit of use, low price of adversarial occasions, and doubtlessly decrease value of the Allurion Program may allow a lot wider software of this important intervention and, finally, assist the tens of millions who battle with weight problems and its related well being issues.”

Supplied by
European Affiliation for the Examine of Weight problems

Quotation:
Combining swallowable gastric balloon and anti-obesity drug may increase weight reduction success (2023, Could 16)
retrieved 16 Could 2023
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