Frequent breast most cancers therapy limits effectiveness of standard weight reduction medication like Ozempic

CHICAGO — A generally used breast most cancers therapy might scale back the effectiveness of weight reduction drugs. In keeping with a brand new research, researchers discovered weight reduction interventions are much less profitable amongst breast most cancers survivors taking aromatase inhibitors in comparison with girls with out breast most cancers who aren’t utilizing these therapies.

Aromatase inhibitors are prescribed to deal with particular kinds of breast most cancers or as a safety measure for high-risk people. They work by blocking an enzyme referred to as aromatase, which the physique makes use of to supply estrogen. By inhibiting aromatase, the drugs scale back estrogen ranges within the physique, thereby inhibiting the expansion of estrogen-dependent most cancers cells.

“Our outcomes spotlight the necessity to develop higher approaches to handle weight acquire in sufferers with a historical past of breast most cancers taking aromatase inhibitors. Stopping weight acquire on this group or treating weight problems successfully will enhance breast most cancers outcomes, stop additional well being issues, and enhance high quality of life for these folks,” says lead researcher Sima Fansa, M.D., of the Mayo Clinic in Rochester, Minn., in a media launch.

Weight acquire and weight problems are related to breast most cancers recurrence, breast cancer-related demise, and elevated danger of coronary heart illness and associated issues.

Weight reduction medication half as efficient

The research included 99 contributors, with 63 girls who had a historical past of breast most cancers and had been taking aromatase inhibitors and weight reduction drugs (liraglutide, semaglutide, or phentermine). The remaining 36 girls didn’t have a historical past of breast most cancers and had been solely taking weight reduction drugs.

The outcomes demonstrated that girls within the breast most cancers group skilled much less weight reduction on the three, six, and 12-month checkpoints in comparison with girls and not using a historical past of breast most cancers. The distinction in weight reduction percentages was noticeable (3.7% vs. 5.6% at 3 months, 3.9% vs. 9.5% at 6 months, and 5.2% vs. 10.5% at 12 months).

Semaglutide Rx medical pills in plastic Bottle
Semaglutide Rx medical capsules in plastic Bottle (Credit score: Shutterstock)

Fansa advised that the anti-estrogen impact of aromatase inhibitors may clarify this distinction. These drugs can result in decreased muscle mass, elevated fats mass, and modifications in vitality expenditure, all of which may influence the physique’s response to weight reduction interventions, together with weight reduction drugs.

The findings underscore the significance of growing improved methods to handle weight acquire in breast most cancers sufferers taking aromatase inhibitors. By stopping weight acquire and successfully addressing weight problems, higher outcomes could be achieved in breast most cancers therapy, lowering the chance of issues and enhancing the standard of life for these people.

Researchers offered their findings on the Endocrine Society’s annual assembly in Chicago.

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