Drugmaker Stories Constructive Outcomes from Weight-loss Tablet

Drugmaker Novo Nordisk says assessments present good weight reduction outcomes from a day by day tablet model of its diabetes remedies.

The corporate sells the drug semaglutide below the names Wegovy and Ozempic. It’s presently accessible solely as a weekly injection.

However some persons are afraid of needles. So, Novo Nordisk has been testing how the drug works when taken by mouth.

Wegovy and Ozempic have gotten a whole lot of consideration within the final 12 months for serving to folks reduce weight. The federal government has accepted the medicine to deal with folks with the illness diabetes. However weight reduction medical doctors additionally give the medicine to chubby individuals who would not have diabetes.

Novo Nordisk stated Sunday that two 16-month research confirmed good outcomes when folks took a day by day tablet as a substitute of a weekly shot.

One research adopted 1,600 chubby adults who have been already being handled for diabetes. They took a tablet model of the drug every day. They misplaced between seven and 9 kilograms.

FILE - A sign for the Food and Drug Administration is displayed outside their offices in Silver Spring, Md., on Dec. 10, 2020. Novo Nordisk plans to ask the FDA to approve their weight loss pill later this year. (AP Photo/Manuel Balce Ceneta, File)

FILE – An indication for the Meals and Drug Administration is displayed outdoors their places of work in Silver Spring, Md., on Dec. 10, 2020. Novo Nordisk plans to ask the FDA to approve their weight reduction tablet later this 12 months. (AP Photograph/Manuel Balce Ceneta, File)

The opposite research checked out 660 chubby individuals who had a weight-related illness apart from diabetes. These folks took a day by day tablet containing 50 milligrams of the medicine. They misplaced about 16 kilograms.

The writers of the research stated the outcomes of the second group have been just like those that obtained the Wegovy injection as soon as per week.

Novo Nordisk stated it expects to ask the U.S. Meals and Drug Administration to approve the capsules for weight reduction later this 12 months.

A number of the folks within the research reported unwanted effects together with intestinal issues, sick abdomen and diarrhea.

Daniel Bessen is a weight reduction physician in Denver. He was not concerned with the research, however he treats sufferers who use weight reduction medicine. He stated, in the event you ask folks, “’Would you somewhat take a tablet or an injection?’ Individuals overwhelmingly desire a tablet.”

He added, nevertheless, that folks may not really feel the identical method if the capsules are extra expensive than the injections. He stated value and availability are a very powerful points for folks when deciding which medicine to take.

Katherine Saunders is a weight reduction physician at Weill Cornell Well being in New York Metropolis. She stated folks might be “thrilled” with the power to take a tablet.

Novo Nordisk already has a tablet type of semaglutide that’s used for diabetes. It’s known as Rybelsus. Nevertheless it comprises much less semaglutide than Wegovy.

High-dose oral versions of the medication in the weight-loss drug Wegovy may work as well as injections at paring pounds and improving health, including hard-to-treat people with diabetes, according to research released Sunday, June 25, 2023. (AP Photo/Patrick Sison, File)

Excessive-dose oral variations of the medicine within the weight-loss drug Wegovy may match in addition to injections at paring kilos and bettering well being, together with hard-to-treat folks with diabetes, based on analysis launched Sunday, June 25, 2023. (AP Photograph/Patrick Sison, File)

Dr. Fatima Cody Stanford is an skilled in treating chubby folks at Massachusetts Common Hospital. She doesn’t suppose the provision of a day by day tablet will change the habits of many individuals who already use the injections. She stated, “Lots of people like the convenience of taking a medicine as soon as every week.”

She additionally stated some folks would possibly desire the pictures to a tablet that must be taken half-hour earlier than consuming or consuming every morning.

Paul Morer is 56 years outdated. He stated he has misplaced about 40 kilograms utilizing Wegovy and doesn’t thoughts the injection. “I do it on Saturday, it’s a part of my routine,” he stated. “I don’t even really feel the needle,” Morer added.

Some folks, nevertheless, suppose the provision of a tablet will make it tougher for overweight folks to be accepted. Tigress Osborn is the chief of an activist group known as the Nationwide Affiliation to Advance Fats Acceptance.

The information of a weight reduction tablet, she stated, might make it laborious for people who find themselves chubby to flee the sensation that “your physique is fallacious, and it ought to change.”

The drug corporations Eli Lilly and Pfizer are additionally engaged on a tablet model of their diabetes drugs for weight reduction.

FILE - The Pfizer logo is displayed on the exterior of a former Pfizer factory, on May 4, 2014, in the Brooklyn borough of New York. Pfizer is one of the companies working on a new weight-loss pill. (AP Photo/Mark Lennihan, File)

FILE – The Pfizer emblem is displayed on the outside of a former Pfizer manufacturing unit, on Could 4, 2014, within the Brooklyn borough of New York. Pfizer is likely one of the corporations engaged on a brand new weight-loss tablet. (AP Photograph/Mark Lennihan, File)

Many of those medicine are so widespread for weight reduction that they’ve change into laborious to get. They’re additionally very expensive – some might be over $1,000 per thirty days. Novo Nordisk stated it couldn’t predict the price of their tablet. The corporate additionally stated injectable Wegovy will proceed to be laborious to get till no less than September.

I’m Dan Friedell. And I am Ashley Thompson.

Dan Friedell tailored this story for Studying English based mostly on a narrative by The Related Press.


Phrases in This Story

tablet –n. a small, spherical, strong quantity of medication or vitamin that’s taken by mouth

somewhat adv. a time period used to declare one factor you would favor over one thing else when given a selection

overwhelming – adj. one thing that’s bigger or better than one thing else

afford–v. the power to pay for one thing

issue–n. one of many issues thought of when evaluating two gadgets as a way to select which one is best

accessible–adj. a measure of how frequent one thing is

thrilled–adj. more than happy or excited

behavior–n. one thing an individual does day by day or typically

routine–n. one thing an individual does day by day or typically


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