Novel weight reduction drug; denosumab vs. alendronate for osteoporosis



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Adults with obese or weight problems, however not kind 2 diabetes, misplaced 14.9% of their physique weight after 46 weeks of receiving BI 456906, a novel glucagon/GLP-1 receptor agonist, throughout a part 2 medical trial, in accordance with a press launch.

“The distinct mode of motion of BI 456906 targets a number of pathways pivotal to metabolic regulation, together with these related to weight problems and liver illnesses,” Carinne Brouillon, head of human pharma for Boehringer Ingelheim, stated within the launch.



Fracture wrist or osteoporosis 2019

Postmenopausal girls with osteoporosis who use denosumab as a first-line remedy had lowers danger for fractures in contrast with girls who use alendronate, in accordance with an business press launch. Picture: Adobe Inventory

It was the highest story in endocrinology final week.

One other prime story coated research outcomes linking Prolia (denosumab, Amgen) to decrease fracture dangers amongst postmenopausal girls than alendronate when used as a first-line osteoporosis remedy. Within the observational, retrospective research, the danger for main osteoporotic fractures continued to lower over 5 years amongst girls utilizing denosumab vs. these utilizing alendronate.

Learn these and extra prime tales in endocrinology under:

Adults with weight problems lose practically 15% of physique weight with glucagon/GLP-1 receptor agonist

A novel glucagon/GLP-1 receptor agonist conferred practically 15% weight reduction at 46 weeks amongst individuals with obese or weight problems with out kind 2 diabetes, in accordance with an business press launch. Learn extra.

Denosumab bests alendronate as first-line remedy for fracture prevention in osteoporosis

Postmenopausal girls with osteoporosis who use denosumab as a first-line remedy have lowers danger for fractures in contrast with girls who use alendronate, in accordance with an business press launch. Learn extra.

Publicity to EDCs might negatively have an effect on thyroid operate, however extra analysis wanted

Repeated publicity to endocrine-disrupting chemical substances might negatively have an effect on thyroid operate, particularly for pregnant girls and infants, however extra analysis is required on the synergistic results, in accordance with a speaker. Learn extra.

About 45% of teenagers with weight problems enhance to obese or regular weight with semaglutide

Practically half of adolescents with weight problems receiving once-weekly subcutaneous semaglutide achieved obese or regular weight at 68 weeks, in accordance with knowledge from the STEP TEENS trial offered through the European Congress on Weight problems. Learn extra.

Oral treatment boosts annualized top velocity amongst kids with GH deficiency

Kids with idiopathic pediatric progress hormone deficiency had a rise in annualized top velocity after 6 months of receiving a every day oral progress hormone remedy, in accordance with a speaker. Learn extra.



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