Novo Nordisk publicizes constructive section 3 outcomes for oral weight-loss drug


Novo Nordisk

Novo Nordisk has introduced constructive outcomes from a section 3a trial of an oral, higher-dose formulation of its weight-loss drug.

Semaglutide is already out there in main markets for weight administration beneath the model names Wegovy and Rybelsus as a once-weekly injection. The drug suppresses sufferers’ appetites by mimicking an intestinal hormone referred to as GLP-1, which is launched after consuming.

The 68-week OASIS 1 examine enrolled 667 adults who have been both overweight or obese with no less than one weight-related well being situation to obtain once-daily oral semaglutide 50mg or placebo.

For the general remedy group, the imply weight reduction from baseline was 15.1% within the semaglutide cohort, in comparison with 2.4% receiving placebo. Moreover, almost 85% of sufferers receiving the drug misplaced no less than 5% of their beginning weight, in comparison with 25.8% on placebo.

The examine additionally evaluated the results of semaglutide on sufferers who adhered nicely to the remedy, with these on this subgroup attaining a weight lack of 17.1%, in comparison with 1.8% with placebo, and almost 90% reaching a weight lack of 5%.

“The outcomes present comparable weight reduction as within the STEP 1 trial with injectable semaglutide 2.4mg in weight problems branded as Wegovy,” defined Martin Holst Lange, government vp for improvement at Novo Nordisk.

”The selection between a day by day pill or weekly injection for weight problems has the potential to supply sufferers and healthcare suppliers the chance to decide on what most accurately fits particular person remedy preferences,” he added.

Novo Nordisk stated it expects to file for regulatory approval for the 50mg oral formulation of the drug within the US and EU this 12 months.

The Well being Survey for England 2021 estimates that 25.9% of adults in England are overweight and an additional 37.9% are obese, with the federal government estimating that the present prices of weight problems within the UK are £6.1bn to the NHS and £27bn to wider society.

The once-weekly injection formulation of semaglutide was really useful by the Nationwide Institute for Well being and Care Excellence in March for adults who’re both overweight or obese with no less than one weight-related well being situation.

The next month, the European Medicines Company’s human medicines committee really useful the drug to be used in adolescents aged 12 years and older with weight problems and a minimal weight of 60kg.



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