Phone-Based mostly Weight Loss Intervention for Sufferers With Breast Most cancers and Chubby/Weight problems




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A randomized examine by Jennifer A. Ligibel, MD, Director of the Leonard P. Zakim Middle for Integrative Therapies and Wholesome Dwelling at Dana-Farber Most cancers Institute, and Affiliate Professor of Medication at Harvard Medical College, evaluating the influence of a telephone-based weight reduction intervention in sufferers with stage II or III breast most cancers and chubby or weight problems has discovered that the intervention resulted in clinically vital weight reduction within the sufferers receiving the intervention in contrast with a management group. In response to the examine’s outcomes, sufferers receiving the intervention misplaced a mean of 4.8% (± 7.9%) of baseline physique weight at 12 months vs 0.8% (± 6.4%) weight achieve within the management group. Additional follow-up of the trial will consider whether or not the burden loss intervention improves illness outcomes. The examine is being introduced throughout the 2023 ASCO Annual Assembly (Summary 12001).

Research Methodology

The BWEL Research (Alliance for Scientific Trials in Oncology A0111401; ClinicalTrials.gov identifier NCT02750826) is evaluating the influence of a weight reduction intervention on invasive illness–free survival in sufferers with breast most cancers and a physique mass index (BMI) of 27 kg/m2 or better. On this a part of the examine, 3,136 eligible sufferers had been inside 14 months of prognosis of stage II or III HER2-negative breast most cancers. The sufferers had accomplished chemotherapy and radiation therapy (if administered) and, between 2016 and 2021, had been randomly assigned 1:1 to a telephone-based weight reduction intervention plus well being training or well being training intervention alone (management group).

The burden loss intervention was delivered by telephone-based well being teaching and centered on caloric restriction and elevated train. Sufferers’ top and weight had been measured at baseline and at 12 months. Evaluation was carried out with univariable and multivariable regression fashions, together with arm, baseline weight, menopausal standing, race/ethnicity, and hormone receptor standing.

A 0.05 stage of significance was used. At baseline, imply BMI was 34.5 (± 5.74) kg/m2, imply age was 53.4 (± 10.58) years, and 57% of the sufferers had been postmenopausal on the time of prognosis. Amongst all individuals, 80.3% had been White, 12.8% had been Black, and seven.3% had been Hispanic. Observe-up weight was out there from 2,293 sufferers disease-free at 12 months.

  • A telephone-based weight reduction intervention induced vital, clinically significant weight reduction in sufferers with stage II/III breast most cancers with chubby or weight problems throughout demographic and tumor elements, however not throughout menopausal standing or race/ethnicity.
  • Longer follow-up of the examine will consider whether or not the intervention improves illness outcomes.

Key Outcomes

The researchers discovered that the burden loss intervention led to a major lower in weight relative to the management group. Sufferers assigned to the burden loss intervention misplaced a mean of 4.8% (± 7.9%) of baseline physique weight at 12 months vs 0.8% (± 6.4%) weight achieve within the management group (P < .0001). Sufferers within the intervention group skilled vital weight reduction (vs controls) throughout demographic and tumor elements; nevertheless, the impact differed considerably by menopausal standing (interplay P worth = .0057) and race/ethnicity (interplay P worth = .019) however not by hormone receptor standing (interplay P worth = .17).

“A telephone-based [weight loss intervention] induced vital, clinically significant weight reduction in breast most cancers sufferers with chubby and weight problems throughout demographic and tumor elements. Extra tailoring of the [intervention] may very well be helpful to boost weight reduction in Black and youthful sufferers. Additional follow-up of the BWEL trial will consider whether or not the [weight loss intervention] improves illness outcomes,” concluded the examine authors.

Future Outlook

Throughout an ASCO premeeting press briefing on this examine, Dr. Ligibel mentioned that longer follow-up of the BWEL trial will decide whether or not dropping pounds after a breast most cancers prognosis improves illness outcomes in these sufferers. “Now that now we have demonstrated our intervention was profitable in inducing weight reduction, we will decide whether or not dropping pounds after a breast most cancers prognosis improved outcomes in these girls, mentioned Dr. Ligibel.

Julie R. Gralow, MD, FACP, FASCO

Commenting on the findings from the examine, Julie R. Gralow, MD, FACP, FASCO, Chief Medical Officer and Govt Vice President of ASCO, mentioned she was wanting ahead to seeing the follow-up information on the examine’s main endpoint, invasive illness–free survival. “Will probably be fascinating to see if weight reduction after the prognosis can really change this poor final result  on the time of prognosis. And I’ll be fascinated to listen to extra in regards to the variations in menopausal standing and race and perhaps some future interventions which may goal these teams that didn’t have as a lot weight reduction,” mentioned Dr. Gralow.

Disclosure: Funding for this examine was offered by the Nationwide Institutes of Well being, Susan G. Komen Basis, Breast Most cancers Analysis Basis, and the American Most cancers Society. For full disclosures of the examine authors, go to conferences.asco.org.

The content material on this publish has not been reviewed by the American Society of Scientific Oncology, Inc. (ASCO®) and doesn’t essentially replicate the concepts and opinions of ASCO®.




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