The unwanted effects of the 2 weight-loss medicine defined by a physician

A woman in an orange shirt using an injection pen on the right side of her stomach.

Injectable weight-loss medicines like tirzepatide and semaglutide can have comparable gastrointestinal unwanted effects.Getty Pictures

  • Two well-liked weight reduction medicine have comparable unwanted effects like diarrhea, nausea, and typically hair loss.

  • Semaglutide, model identify Wegovy or Ozempic, could also be extra prone to trigger gastrointestinal points.

  • Tirzepatide, model identify Mounjaro, acts on a further hormone and should trigger milder, much less frequent signs.

A brand new treatment awaiting FDA approval for weight reduction might have fewer and milder unwanted effects than the at present trending drug semaglutide, in keeping with a weight-loss physician.

Semaglutide, bought underneath the model names Ozempic and Wegovy, has made waves in recent times for inflicting dramatic weight-loss outcomes, however taking it comes with widespread gastrointestinal unwanted effects.

An analogous drug known as tirzepatide, at present bought as Mounjaro, also can trigger points like nausea and diarrhea, however to a lesser diploma stated Dr. Christopher McGowan, a board-certified doctor in inside drugs, gastroenterology, and weight problems drugs.

“The facet impact profile is comparable, and primarily gastrointestinal,” McGowan informed Insider. “The signs are usually gentle to average, and enhance over time.”

Whereas critical unwanted effects are uncommon for each medicines, understanding the distinction can assist individuals select which possibility could also be the perfect match for them, he stated.

Negative effects of Ozempic embrace nausea, diarrhea, and constipation

Semaglutide is a sort of treatment often known as a GLP-1 agonist, which implies it really works by appearing on an insulin-like hormone to control urge for food and digestion, serving to to handle kind 2 diabetes in addition to supporting weight reduction.

It is usually administered by way of once-a-week injections, and sufferers on semaglutide are likely to really feel full extra rapidly, stay full for longer after consuming, and have fewer cravings for meals excessive in energy, fats, and sugar.

The draw back of semaglutide is that some sufferers could also be liable to gastrointestinal signs. In medical trials of the treatment, members mostly reported nausea, vomiting, constipation, diarrhea, headache, and belly ache.

Folks taking semaglutide have additionally informed Insider that the digestive unwanted effects might be intense, inflicting issues like “overflow diarrhea.”

The vast majority of hostile reactions to the drug are usually short-lived, and McGowan and different docs beforehand informed Insider that their largest concern with semaglutide is whether or not sufferers have correct follow-up and help from medical consultants.

The treatment is taken into account to be protected for long-term use, though extra information is required on the way it may work for various demographics over lengthy intervals of time.

Mounjaro may cause gastrointenstinal points like Ozempic, however unwanted effects could also be much less widespread and milder

Tirzepatide can be a once-weekly injection that works on the hormone GLP-1, but it surely has a further impact on one other hunger-related hormone often known as GIP. Like semaglutide, it was initially designed to deal with kind 2 diabetes, however is at present within the strategy of FDA approval for weight reduction.

Some proof suggests the mixed hormone results might result in higher weight reduction outcomes than than these taking semaglutide, though analysis evaluating the 2 medicine head-to-head remains to be underway.

Research of individuals on tirzepatide discovered comparable unwanted effects as semaglutide — nonetheless, they have been much less widespread and fewer extreme. In medical trials, 33% of sufferers on the best dose of tirzepatide reported nausea, in comparison with 44% of semaglutide sufferers. And 23% of tirzepatide sufferers reported diarrhea, in comparison with 31% on semaglutide.

It might be that the “synergistic” impact of the drug’s twin motion on each GLP-1 and GIP might mitigate the gastrointestinal points, in keeping with McGowan.

“It appears the general incidence of unwanted effects is decrease, and whereas it is purely anecdotal, my sufferers who’ve transitioned from semaglutide to tirzepatide say it is significantly better tolerated,” he stated.

Tirzepatide is a comparatively new treatment, and extra analysis can be wanted on the potential long-term results.

“The protection profile is superb, however there are some unknowns, and we wish to observe up with sufferers carefully,” McGowan stated.

Weight-loss medicines can typically trigger hair loss or muscle loss

Studies of sufferers on semaglutide or tirzepatide shedding their hair have change into well-liked on social media and whereas each medicine appear to have that facet impact, it is uncommon and never associated to the medicines themselves, McGowan stated.

“Any intervention that results in vital and probably speedy weight reduction can precipitate hair loss,” he stated. “The excellent news is that hair loss in these cases is nearly at all times non permanent and is mostly as a consequence of a short pause in hair follicle development know as telogen effluvium.”

If sufferers are consuming much less on treatment and do not get sufficient of essential vitamins or energy for vitality total, the chance of unwanted effects like hair loss can improve. The identical lack of energy and vitamins also can trigger a lack of lean muscle mass together with physique fats in some sufferers on weight-loss medicines.

“Typically, I like to recommend specializing in protein consumption when caloric consumption is low, and sustaining dietary stability. And every time potential, I like to recommend that sufferers work with a registered dietitian to make sure that they’re assembly their minimal diet objectives,” McGowan stated.

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