Unraveling the Secret of Sustaining Weight-Loss: Position of Neurotensin Unveiled


Hormone Predicts Ability To Maintain Weight Loss

“You might speculate whether or not the individuals who placed on weight once more merely lack the appetite-inhibiting impact which neurotensin seems to have,” says senior creator Signe Sørensen Torekov. Credit score: Cathrine Sixhøj Chrone (College of Copenhagen)

In quite a few nations at this time, roughly fifty p.c of the inhabitants is chubby, a determine that’s on an upward trajectory. Whereas a big variety of individuals are in a position to shed weight, the difficult side is sustaining that weight reduction.

Current analysis performed on the College of Copenhagen means that the hormone neurotensin may probably function a predictor for a person’s skill to maintain weight reduction.

The examine, which has been revealed within the scientific journal Metabolism, is a so-called proof-of-concept examine, which suggests that it’s the first time that the hormone has been investigated in relation to weight reduction induced by a low-calorie weight loss program.

“Initially, we examined the impact of weight reduction in overweight mice and concluded that weight reduction led to decreased quantity of the hormone neurotensin. Subsequently, in a scientific examine, we discovered that weight reduction additionally led to a decreased quantity of neurotensin in people. Apparently, individuals who maintained weight reduction launched extra neurotensin than individuals who regained weight once more,” explains Professor Signe Sørensen Torekov, who’s the final creator of the examine, on the Division of Biomedical Sciences on the College of Copenhagen.

“It might assist clarify why some individuals are extra profitable than others at sustaining weight reduction.”

Like different urge for food intestine hormones, neurotensin is launched by the intestines once we eat, and the knowledge is compiled within the mind, which can decide whether or not we should always proceed consuming or really feel full.

The contributors misplaced weight throughout the eight-week, low-calorie weight loss program. The researchers concluded that the individuals who misplaced much more weight within the 12 months following the weight loss program launched extra neurotensin than individuals who gained weight after finishing the weight loss program.

“It’s an fascinating outcome. You possibly can speculate whether or not the individuals who placed on weight once more merely lack the appetite-inhibiting impact which neurotensin seems to have,” says Signe Sørensen Torekov.

Learning urge for food hormones to learn the way people could preserve weight reduction

We all know that individuals who have undergone bariatric surgical procedure to drop some pounds launch extra neurotensin after they eat. It was this perception that impressed the researchers to check the impact of neurotensin on weight reduction.

“We all know that different intestine hormones, launched in better quantities after weight problems surgical procedure, assist clarify why individuals who have undergone weight problems surgical procedure are in a position to preserve weight reduction. However nobody had studied the position of neurotensin in reference to diet-induced weight reduction,” says MD and Ph.D. Scholar Joachim Holt, who’s the primary creator of the examine.

Whether or not a drug simulating neurotensin launch within the mind or intestines is fascinating, explains Signe Sørensen Torekov.

“One other fascinating factor about learning these urge for food hormones is to learn the way people could reply to potential remedy and particularly the mixture of a number of urge for food hormones to keep up weight reduction,” says Signe Sørensen Torekov.

Nonetheless, when researchers first found leptin, a key hormone in weight regulation, they realized that quantities drop throughout weight reduction. This might point out that rising the quantity of leptin within the physique would trigger individuals to drop some pounds

“Nevertheless it seems that individuals who reside with weight problems are leptin resistant, which implies that they don’t reply with weight reduction to the hormone. We have no idea whether or not this additionally applies to neurotensin. So we nonetheless have a number of work forward of us.”

Reference: “Elevated meal-induced neurotensin response predicts profitable upkeep of weight reduction – Knowledge from a randomized managed trial” by Annemette Overgaard Brethvad, Hannah Louise Zakariassen, Joachim Holt, Julie Rehné Lundgren, Alexander Jakobsen, Bolette Hartmann, Eva Successful Lehmann, Hannelouise Kissow, Jens Juul Holst, Sten Madsbad, Signe Sørensen Torekov and Birgitte Holst, 16 March 2023, Metabolism.
DOI: 10.1016/j.metabol.2023.155534

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